師資
個人簡介：
張志榮博士，博士生導(dǎo)師，副研究員，南方科技大學(xué)醫(yī)學(xué)院生物化學(xué)系助理教授。于2013年在廈門大學(xué)獲得博士學(xué)位；隨后加入法國遺傳與分子細(xì)胞生物學(xué)研究所 (IGBMC) 進(jìn)行博士后研究工作；于2023年12月以助理教授身份加入南方科技大學(xué)醫(yī)學(xué)院，帶領(lǐng)獨立課題組。長期聚焦于先天免疫反應(yīng)分子機(jī)制的研究，并取得一系列原創(chuàng)性成果，以第一作者或兼共通訊作者將相關(guān)工作發(fā)表在Nature Immunology、Journal of Experimental Medicine、EMBO Reports和Journal of Immunology上，同時以共一兼共通訊作者的研究工作即將在Science Immunology上發(fā)表，另外以合作作者身份參與的研究工作在Science、Nature Cell Biology、Nature Metabolism、Nature Communications和Cell Reports等雜志上發(fā)表。谷歌學(xué)術(shù)引用次數(shù)超過2000次，H-index為16.
教育背景：
· 09/2007 - 07/2013, 動物學(xué)博士, 廈門大學(xué)
· 09/2003 - 07/2007, 生物技術(shù)基地學(xué)士, 內(nèi)蒙古大學(xué)
工作經(jīng)歷：
· 12/2023至今，助理教授，南方科技大學(xué)醫(yī)學(xué)院
· 09/2013 - 11/2023, 博士后, 法國遺傳與分子細(xì)胞生物學(xué)研究所(IGBMC)
獲獎情況及榮譽：
· USIAS博士后獎學(xué)金, 2017
· EMBO meeting旅行津貼(travel grant), 德國曼海姆, 2016
· EFSD/CDS/Lilly項目, 2013
· 國家獎學(xué)金, 內(nèi)蒙古大學(xué), 2006
研究領(lǐng)域：
將結(jié)合分子生物學(xué)、細(xì)胞生物學(xué)、遺傳學(xué)、生物化學(xué)和結(jié)構(gòu)生物學(xué)等手段來研究：1) 激活先天免疫反應(yīng)的分子機(jī)制，主要聚焦于炎癥小體的組裝和激活；2) 病原體與宿主相互作用的分子機(jī)制；3) 感染性疾病的發(fā)病機(jī)理。
學(xué)術(shù)任職：
· Frontiers in Cell Death審稿編輯
· Frontiers in Immunology審稿編輯
· Frontiers in Immunology客座編輯
發(fā)表論文：
[24] Ran L*, Ye T, Erbs E, Ehl S, Spassky N, Sumara I, Zhang Z*# and Ricci R#. KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation. Science Immunology, in press (#corresponding authors; *equal contribution).
[23] Ran L*, Ye T, Erbs E, Sumara I, Ricci R#, Zhang Z*#. KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation. BioRxiv, doi: https://doi.org/10.1101/2023.03.08.531717 (#corresponding authors; *equal contribution).
[22] Zhang Z#*, Venditti R*, Ran L, Liu Z, Vivot K, Schurmann A, Bonifacino J, de Matteis A#, Ricci R#. Distinct changes in endosomal composition promote NLRP3 inflammasome activation. Nature Immunol. 2023 Jan; 24(1):30-41. (#corresponding authors; *equal contribution)
[21] Zhang Z#, Ricci R#. Hijacking the NLRP3 inflammasome: a mechanism underlying viral respiratory disease? EMBO Rep 2020; 21(7): e50645. (#corresponding authors)
[20] Zhang Z, Meszaros G*, He W*, Xu Y, de Fatima Magliarelli H, Mailly L, Mihlan M, Liu Y, Gámez M, Goginashvili A, Pasquier A, Bielska O, Neven B, Quartier A, Aebersold R, Baument TF, Georgel P, Han J, Ricci R. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med 2017; 214 (9): 2671-2693. (*equal contribution)
[19] Zhang Z*, Xu X*, Ma J, Wu J, Wang Y, Zhou R, Han, J. Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses. J. Immunol. 2013; 190(7):3517-24. (*equal contribution)
[18] Vivot K, Meszaros G, Zhang Z, Erbs E, Yeghiazaryan G, Qui?ones M, Grandgirard E, Schneider A, Clauss-Creusot E, Charlet A, Faour M, Martin C, Luquet E, Kloppenburg P, Nogueiras R, Ricci R. CaMK1D signaling in AgRP neurons promotes ghrelin-mediated food intake. Nature Metabolism, 2023, 5(6):1045-1058.
[17] Goginashvili A, Zhang Z, Erbs E, Spiegelhalter C, Kessler P, Mihlan M, Pasquier A, Krupina K, Schieber N, Cinque L, Morvan J, Sumara I, Schwab Y, Settembre C, Ricci R. Insulin secretory granules control autophagy in pancreatic β cells. Science 2015; 347:878–882.
[16] Niu T, De Rosny C, Chautard S, Rey A, Patoli D, Groslambert M, Cosson C, Lagrange B, Zhang Z, Visvikis O, Hacot S, Hologne M, Walker O, Wong J, Wang P, Ricci R, Henry T, Boyer L, Petrilli V, Py B. NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly. Nat Commun 2021; 12(1):5862
[15] Pangou E*, Bielska O*, Guerber L, Schmucker S, Agote-Aran Arantxa, Ye T, Liao Y, Puig-Gamez M, Grandgirard E, Kleiss C, Liu Y, Compe E, Zhang Z, Aebersold R, Ricci R#, Sumara I#. A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression. Cell Rep 2021; 35(7):109129. (#corresponding authors; *equal contribution)
[14] Pasquier A, Vivot K, Erbs E, Spiegelhalter C, Zhang Z, Aubert V, Liu Z, Senkara M, Maillard E, Pinget M, Kerr-Conte J, Pattou F, Marciniak G, Ganzhorn A, Ronchi P, Schieber N, Schwab Y, Saftig P, Goginashvili A#, Ricci R#. Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes. Nat Commun 2019;10(1):3312. (#corresponding authors)
[13] Ma H, Liu Z, Zhong C, Liu Y, Zhang Z, Liang Y, Li J, Han S, Han J. Inactivation of cyclic AMP response element transcription caused by constitutive p38 activation is mediated by hyperphosphorylation-dependent CRTC2 nucleocytoplasmic transport. Mol Cell Biol 2019; 39(9): e00554-18.
[12] Xu Y, Ma H, Fang L, Zhang Z, Shao J, Hong M, Huang C, Liu J, Chen R. Cisplatin-induced necroptosis in TNFα dependent and independent pathways. Cell Signal 2017; 31:112-123.
[11] de Fatima Magliarelli H, Matondo M, Mészáros G, Goginashvili A, Erbs E, Zhang Z, Mihlan M, Wolfrum C, Aebersold R, Sumara I, Ricci R. Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3. Cell Death Dis 2016; 7(10):e2411.
[10] Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Su S, Zheng X, Zhang Z, Zhong C, Wan H, Xiao M, Lin X, Feng X, Han J. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat. Cell Biol. 2015 17, 434–444.
[9] Xu Y, Ma H, Shao J, Wu J, Zhou L, Zhang Z, Wang Y, Huang Z, Ren J, Liu S, Chen X, Han J. A Role for Tubular Necroptosis in Cisplatin-Induced AKI. J. Am. Soc. Nephrol. 2015; 26:2647–2658.
[8] Xu X, Leng J, Gao F, Zhao Z, Deng W, Liang X, Zhang Y, Zhang Z, Li M, Sha A, Yang Z. Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization. FEBS Lett. 2014 ; 588: 1580–1589.
[7] Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y, Zhou X, Yang Z, Wu S, Chen L, Han J. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res. 2013; 23:994–1006.
[6] Lin J*, Li H*, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J, Han J. A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development. Cell Rep 2013; 3:200-210. (*equal contribution)
[5] Zhang X, Liang X, Wang T, Liang X, Zuo R, Deng W, Zhang Z, Qin F, Zhao Z, Yang Z. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization. Mol. Cell. Endocrinol. 2013; 381:272–279
[4] Lei W, Feng X, Deng W, Ni H, Zhang Z, Jia B, Yang X, Wang T, Liu J, Su R, Liang X, Qi, Q, Yang Z. Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice. J Biol Chem 2012; 287:15174-15192.
[3] Zhao Z, Zhang Z, Xu X, Deng W, Li M, Leng J, Liang X, Yang Z. Arachidonic acid regulation of the cytosolic phospholipase A 2alpha/cyclooxygenase-2 pathway in mouse endometrial stromal cells. Fertil Steril 2012; 97 :1199-1205 e1191-1199.
[2] Tian Z, Zhao Z, Liang X, Zhang X, Sha A, Zhang Z, Yu Y, Yang, Z. Expression and function of fatty acid-binding protein 4 during mouse decidualization. Fertil Steril 2011; 95:2749-2752 e2741-2745.
[1] Su R, Lei W, Liu J, Zhang Z, Jia B, Feng X, Ren G, Hu S, Yang Z. The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation. PLoS One 2010; 5:e15513.