梁征宇2012年本科畢業(yè)于華中科技大學(xué)生物信息技術(shù)專業(yè)，2018年博士畢業(yè)于清華大學(xué)生物學(xué)專業(yè)（導(dǎo)師張奇?zhèn)ソ淌冢?018-2023年于加州大學(xué)圣地亞哥分校細(xì)胞與分子醫(yī)學(xué)系從事博士后研究（導(dǎo)師付向東教授），于2023年4月全職回國(guó)加入南方科技大學(xué)生命科學(xué)學(xué)院，擔(dān)任助理教授，博士生導(dǎo)師，獨(dú)立課題組長(zhǎng)（PI）。
梁征宇博士致力于功能基因組學(xué)的研究，運(yùn)用生物信息學(xué)及細(xì)胞和分子生物學(xué)方法，研究基因組三維空間結(jié)構(gòu)、基因轉(zhuǎn)錄調(diào)控、RNA代謝及功能等系列科學(xué)問題，特別是研究腫瘤中染色體外DNA（extrachromosomal DNA）的結(jié)構(gòu)與功能，以第一作者（含共同）身份在Cell、Circulation、Nature Communication、Cell Reports等國(guó)際期刊上發(fā)表研究論文多篇。
Xiao, R.*, Chen, J.-Y.*, Liang, Z.*, Luo, D., Chen, G., Lu, Z.J., Chen, Y., Zhou, B., Li, H., and Du, X. (2019). Pervasive chromatin-RNA binding protein interactions enable RNA-based regulation of transcription. Cell 178, 107-121. e118.
Liang, Z., Li, G., Wang, Z., Djekidel, M.N., Li, Y., Qian, M.-P., Zhang, M.Q., and Chen, Y. (2017). BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions. Nature communications 8, 1622.
Liang, Z., and Fu, X.-D. (2021). 3D genome encoded by LINE and SINE repeats. Cell Research 31, 603-604.
Wu, T.*, Liang, Z.*, Zhang, Z., Liu, C., Zhang, L., Gu, Y., Peterson, K.L., Evans, S.M., Fu, X.-D., and Chen, J. (2022). PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle. Circulation 145, 586-602.
Song, Y.*, Liang, Z.*, Zhang, J.*, Hu, G.*, Wang, J., Li, Y., Guo, R., Dong, X., Babarinde, I.A., and Ping, W. (2022). CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming. Cell Reports 39, 110626.
Qian, H., Kang, X., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang, X., Xue, Y., Maimon, R., and Dowdy, S.F. (2020). Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582, 550-556.
Gou, L.-T., Lim, D.-H., Ma, W., Aubol, B.E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., and Zhang, X. (2020). Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation. Cell 180, 1212-1227. e1214.
Qiu, Z., Zhao, L., Shen, J.Z., Liang, Z., Wu, Q., Yang, K., Min, L., Gimple, R.C., Yang, Q., and Bhargava, S. (2022). Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem CellsTargeting Transcription Machinery Potentiates Immunotherapy. Cancer discovery 12, 502-521.
Zhu, S., Nguyen, A., Pang, J., Zhao, J., Chen, Z.e., Liang, Z., Gu, Y., Huynh, H., Bao, Y., and Lee, S. (2022). Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy. Circulation 146, 1028-1031.
