師資
個人簡介
裴勇剛，微生物學博士，美國賓夕法尼亞大學博士后，現(xiàn)擔任公共衛(wèi)生及應急管理學院助理教授，主要研究方向為皰疹病毒感染、腫瘤病毒致病、病毒與宿主互作、高通量測序分析、藥物靶向治療。現(xiàn)已在PLOS Pathogens、Journal of Virology、eLife、Annual Review of Virology等國際專業(yè)期刊發(fā)表論文近20篇，參編學術(shù)論著2部，申請國際專利1項，并擔任Frontiers in Microbiology、Pathogens等多個國際專業(yè)雜志審稿人。
研究方向
1. 皰疹病毒潛伏感染維持和激活的分子機制
2. 高通量測序鑒定腫瘤病毒致癌的關(guān)鍵因子
3. 腫瘤病毒致癌過程中的染色質(zhì)修飾和轉(zhuǎn)錄調(diào)控機制
4. 皰疹病毒致病和新發(fā)傳染病的相互作用關(guān)系
工作經(jīng)歷
2021-至今，南方科技大學，公共衛(wèi)生及應急管理學院，助理教授
2019-2021，美國賓夕法尼亞大學，醫(yī)學院，研究助理
2014-2019，美國賓夕法尼亞大學，醫(yī)學院，博士后
教育背景
2009-2014，武漢大學，生命科學學院，國家病毒學重點實驗室，理學博士
2004-2008，中國地質(zhì)大學（武漢），環(huán)境學院，生物科學學士
學術(shù)成果（*共同第一作者，#通訊作者）
1. Singh RK, Pei Y, Lamplugh ZL, Sun K, Yuan Y, Lieberman PM, You J, Robertson ES. 2021. KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia. eLife, 10, e57436.
2. Pei Y, Robertson ES. 2020. The crosstalk of epigenetics and metabolism in herpesvirus infection. Viruses. 2020, 12, 1377.
3. Pei Y, Hwang N, Lang F, Zhou L, Wong JH-y, Singh RK, Jha HC, El-Deiry WS, Du Y, Robertson ES. 2020. Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform. Communications Biology 3:267.
4. Pei Y, Wong JH-y, Jha H, Tian T, Wei Z, Robertson ES. 2020. Epstein-Barr Virus facilitates expression of KLF14 by regulating the cooperative binding of E2F-Rb-HDAC complex in latent infection. J Virol doi:10.1128/JVI.01209-20.
5. Pei Y, Wong JH-y, Robertson ES. 2020. Herpesvirus epigenetic reprogramming and oncogenesis. Annual Review of Virology, 7, 309-331, doi:10.1146/annurev-virology-020420-014025.
6. Pei Y, Wong JH-y, Robertson ES. 2020. Targeted therapies for Epstein-Barr Virus-associated lymphomas. Cancers 12(9):2565, doi:10.3390/cancers12092565.
7. Hwang N*, Pei Y*, Clement J, Robertson ES, Du Y. 2020. Identification of a 3-β-homoalanine Conjugate of Brusatol with Reduced Toxicity in Mice. Bioorganic & Medicinal Chemistry Letters 30, 127553, doi:10.1016/j.bmcl.2020.127553. (*Contributed equally)
8. Crocker KE, Pei Y, Robertson ES, Winkler J. 2020. Synthesis of a Novel Bruceantin Analog via Intramolecular Etherification. Canadian Journal of Chemistry doi:10.1139/cjc-2019-0437.
9. Zhang S, Pei Y, Lang F, Sun K, Singh RK, Lamplugh ZL, Saha A, Robertson ES. 2019. EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation. PLoS Pathog 15(1): e1007514.
10. Lang F, Singh RK, Pei Y, Zhang S, Sun K, Robertson ES. 2019. EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis. PLoS Pathog 15(6): e1007796.
11. Lang F, Pei Y, Lamplugh ZL, Robertson ES. 2019. Molecular Biology of EBV in Relationship to HIV/AIDS-Associated Oncogenesis. In: Meyers C. (eds) HIV/AIDS-Associated Viral Oncogenesis. Cancer Treatment and Research, vol 177. Springer, Cham.
12. Pei Y, Singh RK, Shukla SK, Lang F, Zhang S, Robertson ES. 2018. Epstein–Barr Virus nuclear antigen 3C facilitates cell proliferation by regulating Cyclin D2. J Virol doi:10.1128/JVI.00663-18.
13. Singh RK, Lang F, Pei Y, Jha HC, Robertson ES. 2018. Metabolic reprogramming of Kaposi’s sarcoma-associated herpes virus-infected B-cells in hypoxia. PLoS Pathog 14: e1007062.
14. Lang F, Sun ZG, Pei Y, Singh RK, Jha HC, Robertson ES. 2018. Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy. PLoS Pathog 14:e1007253.
15. Pei Y, Banerjee S, Jha HC, Sun Z, Robertson ES. 2017. An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation. PLoS Pathog 13: e1006500.
16. Pei Y, Lewis AE, Robertson ES. 2017. Current Progress in EBV-Associated B-Cell Lymphomas. In: Cai Q., Yuan Z., Lan K. (eds) Infectious Agents Associated Cancers: Epidemiology and Molecular Biology. Advances in Experimental Medicine and Biology, vol 1018. Springer, Singapore.
17. Pei Y*, Banerjee S*, Sun Z, Jha HC, Saha A, Robertson ES. 2016. EBV Nuclear Antigen 3C Mediates Regulation of E2F6 to Inhibit E2F1 Transcription and Promote Cell Proliferation. PLoS Pathog 12:e1005844. (*Contributed equally)
18. Jha H, Pei Y, Robertson E. 2016. Epstein Barr virus: Diseases linked to Infection and Transformation. Frontiers in microbiology 7:1602.
19. Sun Z, Jha HC, Pei Y, Robertson ES. 2016. Major Histocompatibility Complex Class II HLA-DRalpha Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8. J Virol 90:8047-8058.
20. Pei Y*, Fu W*, Yang E*, Shen A, Chen YC, Gong H, Chen J, Huang J, Xiao G, Liu F. 2012. A Hsp40 chaperone protein interacts with and modulates the cellular distribution of the primase protein of human cytomegalovirus. PLoS Pathog 8:e1002968. (*Contributed equally)
21. Shen A, Lei J, Yang E, Pei Y, Chen YC, Gong H, Xiao G, and Liu F. 2011. Human cytomegalovirus primase UL70 specifically interacts with cellular factor Snapin. J Virol 85:11732-11741.