基本概況
李職秀博士，公共衛(wèi)生及應急管理學院副教授（研究員），博士生導師。主要研究方向為免疫疾病等慢病和復雜疾病的致病機理，早期診斷和精準干預，以及傳染性疾病疫苗的開發(fā)。曾主持和參與多項澳大利亞國家級、州政府級和企業(yè)科研項目。在Nature Genetics, Annals of the Rheumatic Diseases, PLos Genetics, Nature Reviews Rheumatology, Annal Review of Biophysics等權威SCI雜志發(fā)表論文40余篇 。現(xiàn)為Frontiers in Immunology 雜志客座編輯。曾擔任Nature Genetics, Nature Communications, Arthritis & Rheumatology, JAMA Network Open等多個SCI期刊審稿專家。曾任澳大利亞、英國和法國等國際基金會的通訊評審。多次在American College of Rheumatology年會，亞太風濕病學會聯(lián)盟大會（APLAR）等國際會議上做大會報告和口頭學術報告，獲得2019 APLAR最佳摘要獎。為國際強直性脊柱炎遺傳學聯(lián)盟（International Genetics of Ankylosing Spondylitis，IGAS）成員。
研究方向
1． 免疫疾病等慢病和復雜疾病的遺傳和非遺傳病因
2． 強直性脊柱炎等疾病的早期診斷，精準干預和管理，以及相關方法的開發(fā)
3． 針對重大傳染性疾病和病毒的精準疫苗設計
工作經歷
2023.12-至今 南方科技大學，公共衛(wèi)生與應急管理學院，副教授
2023.06-2023.12 南方科技大學，公共衛(wèi)生與應急管理學院，助理教授
2018-2022 昆士蘭科技大學 Vice-Chancellor Research Fellow
2016-2018 昆士蘭科技大學 博士后
2014-2016 昆士蘭大學 博士后
教育經歷
2009-2015 印第安納大學 信息學院 博士
2005-2009 中國科學技術大學 生命科學院 學士
代表性論文（#共同一作，*通訊作者）
1. Li, Z., McRae, A. F., Wang, G., et al. Genotype by sex interactions in ankylosing spondylitis. Nat. Genet. 55, 14–16 (2023).
2. Li, Z., Khan, M. K., Linden, S. M. van der, et al. HLA-B27, axial spondyloarthritis and survival. Ann. Rheum. Dis. (2023) doi:10.1136/ard-2023-224434.
3. Li, Z., Linden, S. M. van der, Khan, M. A., et al. Heterogeneity of axial spondyloarthritis: genetics, sex and structural damage matter. RMD Open 8, e002302 (2022).
4. Williams, C. J#., Li, Z.#, Harvey, N#., et al. Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study. J. Biomed. Sci. 28, 37 (2021).
5. Li, Z., Wu, X., Leo, P. J., et al. Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis. Ann. Rheum. Dis. 80, 1168–1174 (2021).
6. Wang, G., Kim, T.-H., Li, Z.#, et al. MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions. Arthritis Res. Ther. 22, 74 (2020).
7. Li, Z., Akar, S., Yarkan, H., et al. Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis. PLOS Genet. 15, e1008038 (2019).
8. Li, Z. & Brown, M. A. Progress of genome-wide association studies of ankylosing spondylitis. Clin. Transl. Immunol. 6, e163 (2017).
9. Li, Z., Haynes, K., Pennisi, D. J., et al. Epigenetic and gene expression analysis of ankylosing spondylitis-associated loci implicate immune cells and the gut in the disease pathogenesis. Genes Immun. 18, 135–143 (2017).
10. Li, Z., Yang, Y., Faraggi, E., Zhan, J. & Zhou, Y. Direct prediction of profiles of sequences compatible with a protein structure by neural networks with fragment-based local and energy-based nonlocal profiles. Proteins Struct. Funct. Bioinforma. 82, 2565–2573 (2014).
11. Li, Z., Yang, Y., Zhan, J., Dai, L. & Zhou, Y. Energy Functions in De Novo Protein Design: Current Challenges and Future Prospects. Annu. Rev. Biophys. 42, 315–335 (2013).
