Faculty
SELF-INTRODUCTION：
Personal Profile: Xingyin Liu is a Professor in the Department of Biochemistry at the School of Medicine, Southern University of Science and Technology. In 2023, she was honored with the title of Outstanding Female Scientist by the Chinese Biophysical Society. In 2024, she was selected as one of the Most Influential and Popular Chinese Authors by Cell Press. Professor Liu currently serves as an Associate Editor or Editorial Board Member for several international journals, including Microbiological Research and iMeta, etc. She is also a reviewer and guest editor for over 30 international authoritative journals, such as Cell Host & Microbe, Gut, Cell Genomics, Cell Reports, Cell Reports Medicine, Microbiome, and Gut Microbes, etc. She has published nearly 60 SCI-indexed papers, with over 40 as the corresponding or first author in prestigious journals like Cell Host & Microbe, Cell Metabolism, Gut, Gut Microbes, Npj Biofilm & Microbiome, and Genome Medicine. Her two patents have been translated into clinical practice.
EDUCATION:
1992-1996 B.S.in Microbiology, Sichuan University (四川大學)
2001-2006 Ph.D. in Genetics, University of Sen Yat-Sun (中山大學)
RESEARCH FIELD:
1. Research on the role and mechanisms of microbiota in the pathogenesis and progression of neurological disorders and tumorigenesis;
2. Regulatory mechanisms of gut microbiota on neuroimmune system;
3. Identification and functional characterization of natural probiotics;
4. Synthetic biology: Developing engineered bacteria for targeted disease treatment;
WOKRING EXPERIENCE:
Dec of 2024 to Now, Professor, Department of Biochemistry, School of Medicine, Southern University of Science and Technology
Oct of 2015-Dec of 2024 Professor, Department of Microbiology, Nanjing Medical University, China.
2019-2024 Professor, State Key Laboratory of Reproductive Medicine and offspring health, Nanjing Medical University
2006–2010 Postdoctoral Research Associate, Department of Medicine, University of Rochester, NY. USA
2010-2015 Research fellow, Department of Genetics, Albert Einstein College of medicine, Yeshiva University, NY, USA.
July of 2015- Oct of 2015, Associate, Department of Genetics Albert Einstein College of Medicine, Bronx, NY
HONORS AND AWARDS:
2024: Top Ten Graduate Supervisors at Nanjing Medical University
2024 :The most picked award of 2023 Chinese Scientists with Cell Press
2024: Excellent Ph.D thesis Supervisor of Nanjing Medical University
2024 :International Genetically Engineered Machine Competition (iGEM) Gold Award
2023: The outstanding Female Scientist of The Biophysical Society of China
2022: International Genetically Engineered Machine Competition (iGEM) Gold Award
2022: 333 High-level Talents in Jiangsu Province (Second level)
2021: Excellent Master thesis Supervisor of Nanjing Medical University
2021: First Prize of Huaxia Medical Science and Technology Award (Winner: Research on the mechanism of infertility and Birth Defects caused by Genetic and Environmental factors, ranked second)
2021: International Genetically Engineered Machine Competition (iGEM) Gold Award and the Most Inclusive Research Design Award
2020/2021: Excellent Master thesis Supervisor of Nanjing Medical University
2020: International Genetically Engineered Machine Competition (iGEM) Gold Award
2019: Excellent academic commination Award for Chinese Society for Microbiology
2017: Distinguished Professor of Jiangsu Province
2016: Special Medical expert of Jiangsu Province
2006: Joint training Ph.D candidate Scholarship of Sun Yat-Sen University and Hong Kong Polytechnic University (2003-2006)
2005:The prize for Nanyue Outstanding graduate student of Guangdong, Province
2003: Outstanding Ph.D candidate Scholarship, Sun Yat-Sen University
2002: Outstanding graduate student Scholarship, Sun Yat-Sen University
Academic Positions/Affiliations:
Vice Chairman of the Microecology and Health Committee of the China Medical Education Association;
Vice Chairman of the Medical Genetics Professional Committee of the China Eugenics Science Association;
Committee Member of the Child Cognition and Brain Dysfunction Branch of the Chinese Society for Neuroscience;
Committee Member of the Gut Microbiota Society under the Chinese Biophysical Society;
Representative Publications (*corresponding authors):
1. Zhang Q, Zhao Q, Li T, Lu L, Wang F, Zhang H, Liu Z, Ma H, Zhu Q, Wang J, Zhang X, Pei Y, Liu Q, Xu Y, Qie J, Luan X, Hu Z, Liu X*. Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity. Cell Metabolism. 2023;35(6):943-960.e9.
2. Lou M, Cao A, Jin C, Mi K, Xiong X, Zeng Z, Pan X, Qie J, Qiu S, Niu Y, Liang H, Liu Y, Chen L, Liu Z, Zhao Q, Qiu X, Jin Y, Sheng X, Hu Z, Jin G*, Liu J*, Liu X*, Wang Y*. Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder. GUT. 2022; 71(8):1588-1599.
3. Chen K, Luan X, Liu Q, Wang J, Chang X, Snijders AM, Mao J-H, Secombe J, Dan Z, Chen J-H, Wang Z, Dong X, Qiu C, Chang X, Zhang D, Celniker SE, Liu X*. Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance. Cell Host & Microbe. 2019,25:537-552.e8.
4. Mi K, Xu R, Liu X*. Rfw captures species-level metagenomic functions by integrating genome annotation information. Cell Reports Methods. 2024; 4(12):100932.
5. Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X*. Altered gut microbial profile is associated with abnormal metabolism activity of autism spectrum disorder. Gut Microbes. 2020;00:1-22.
6. Liu Z, Zhang Q, Zhang H, Yi Z, Ma H, Wang X, Wang J, Liu Y, Zheng Y, Fang W, Huang P, Liu X. Colorectal cancer microbiome programs DNA methylation of host cells by affecting methyl donor metabolism. Genome Med. 2024;16(1):77.
7. Liu Z, Mi K, Xu ZZ, Zhang Q, Liu X*. PM2RA: A Framework for Detecting and Quantifying Relationship Alterations in Microbial Community. Genomics, proteomics & bioinformatics. 2021; DOI:10.1016/j.gpb.2020.07.005.
8. Mi K, Li Y, Yang Y, Secombe J, Liu X*. DVT: a high-throughput analysis pipeline for locomotion and social behavior in adult Drosophila melanogaster. Cell Biosci. 2023;13(1):187.
9. Shen X, Yang Z, Wang Q, et al., Liu X*, Mo X. Lactobacillus plantarum L168 improves hyperoxia-induced pulmonary inflammation and hypoalveolarization in a rat model of bronchopulmonary dysplasia. Npj biofilms and microbiomes. 2024;10(1):32.
10. Cheng Y, Tan G, Zhu Q, et al., Liu X (Co-corresponding author), Huang H, Wei Y. Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design. Gut Microbes. 2023;15(2):2284247.
11. Xu Y, Wang F, Mi K, et al., Liu X* (Corresponding author). Biglycan regulated colorectal cancer progress by modulating enteric neuron-derived IL-10 and abundance of Bacteroides thetaiotaomicron. iScience. 2023;26(9):107515.
12. Liu Z, Zhang X, Zhang H, Zhang H, Yi Z, Zhang Q, Liu Q, Liu X*. Multi-Omics Analysis Reveals Intratumor Microbes as Immunomodulators in Colorectal Cancer. Microbiol Spectr. 2023;1(2):e0503822.
13. Liu Z, Mao X, Dan Z, et al., Liu X*. Gene variations in autism spectrum disorder are associated with alteration of gut microbiota, metabolites and cytokines. Gut microbes. 2021;13(1):1-16.
14. Mi K, Xu Y, Li Y, Liu X*. QMD: A new method to quantify microbial absolute abundance differences between groups. iMeta. 2023;DOI:10.1002/imt2.78.
15. Xu L, Zhang Q, Dou X, Wang Y, Wang J, Zhou Y, Liu X*, Li J. Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice. J Genet Genomics. 2022;9(11):1042-1052.
16. Wang J, Liu Z, Xu Y, et al., Liu X*. Enterobacterial LPS-inducible LINC00152 is regulated by histone lactylation and promotes cancer cells invasion and migration. Front Cell Infect Microbiol. 2022;12:913815. PMID: 35959377.
17. Zhang R, Zhang Q, Chen Y, Zhao Q, et al., Liu X*, Ni M, Jiang B. Combined treatment with Rg1 and adipose-derived stem cells alleviates DSS-induced colitis in a mouse model. Stem Cell Res Ther. 2022;13(1):272.
18. Wang J, Qie J, Zhu D, et al., Liu X*. The landscape in the gut microbiome of long lived families reveals new insights on longevity and aging-relevant neural and immune function. Gut Microbes. 2022;4(1):2107288.
19. Liu X, Secombe J*. The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif. Cell Rep. 2015;13(10):2219-31.
20. Liu X, Greer C, Secombe J*. KDM5 interacts with Foxo to modulate cellular levels of oxidative stress. PLoS Genet. 2014;10(10):e1004676.
21. Liu C, Lu Q, Xi Q, Xiao S, Du J, Qin R, Wang J, Xu B, Han X, Zhou K, Tao S, Lv H, Jiang Y, Jiang T, Ye K, Jin G, Ma H, Xia Y, Shen H, Liu X*, Lin Y*, Hu Z*. Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes. J Genet Genomics. 2025;S1673-8527(25)00030-X.
Invited reviews and insights
1. Wang Q, Yang Q, Liu X*. The microbiota-gut-brain axis and neurodevelopmental disorders. Protein Cell. 2023 25;14(10):762-775.
2. Lin X, Yu Z, Liu Y, Li C, Hu H, Hu JC, Liu M, Yang Q, Gu P, Li J, Nandakumar KS, Hu G, Zhang Q, Chen X, Ma H, Huang W, Wang G, Wang Y, Huang L, Wu W, Liu NN*, Zhang C*, Liu X*, Zheng L*, Chen P*. Gut-X axis. Imeta. 2025; 26;4(1):e270.
3. Liu X*, The interaction of gut microbiota, genetic variation, and diet in autism spectrum disorder, mLife, 2022, 1(3): 241-244.
4. Zhao Q, and Liu X *. 腸道微生物在孤獨癥中的研究進展 [J]. SCIENTIA SINICA Vitae, 《中國科學》,2023, 605-15.
5. Li Ye, Wang X, and Liu X*. 微生物藥物在神經系統疾病中的研究進展 [J]. Chinese Bulletin of Life Sciences: 《生命科學》296-306, 2023, 35(3): 296-306.