FANG Liang
Research Associate Professor
fangl@sustc.edu.cn
Education：
2013 Humboldt University of Berlin Ph.D. (Cell Biology)
2007 College of Pharmaceutical Sciences, Zhejiang University M.Sc. Med. (Pharmacology)
2005 Zhejiang University B.Sc. Med. (Pharmaceutical Sciences) & B.Sc. (Biotechnology)
Work Experience：
2017-present Southern University of Science and Technology Research Associate Professor
2013-2017 Max Delbrück Center for Molecular Medicine Postdoc
2007-2008 Charité University Medicine Research Assistant
Research Areas：
Establish organoid culture platform from patient material, and develop economic, stable new materials for organoid culture.
Model the development of tumor formation with organoid culture, study the interplay between tumor-associated mutations, and identify biomarkers for tumor diagnostic.
Publications：
Zhu Q*, Fang L*, Heuberger J, Kranz A, Schipper J, Scheckenbach K, Vidal RO, Sunage-Franze DY, Müller M, Wulf-Goldenberg A, Sauer S, Birchmeier W. The Wnt-driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Cell Reports 2018 accepted. (Co-first author)
Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Birchmeier W. A small-molecule antagonist of the beta-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis. Cancer Research 2016 Feb 15;76(4):891-901.
Holland JD, Gyorffy B, Vogel R, Eckert K, Valenti G, Fang L, Lohneis P, Elezkurtaj S, Ziebold U, Birchmeier W. Combined Wnt/beta-Catenin, Met, and CXCL12/CXCR4 Signals Characterize Basal Breast Cancer and Predict Disease Outcome. Cell Reports 2013;5(5):1214-27.
Wend P, Fang L, Zhu Q, Schipper JH, Loddenkemper C, Kosel F, Brinkmann V, Eckert K, Hindersin S, Holland JD, Lehr S, Kahn M, Ziebold U, Birchmeier W. Wnt/beta-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. Embo J. 2013 Jul 17;32(14):1977-89.
