Research Interests
◆ The role of cell-matrix adhesion complex including PINCH-ILK-Parvin and Kindlin-migfilin in renal disease.
◆ The role of cell-matrix adhesion complex in tumor metastasis.
◆ The role of adenosine in the inflammation.
Education Backgound
◆ 2005-2010 Ph.D., Hong Kong University of Science and Technology;
◆ 2001-2004 M.S., Nankai University;
◆ 1997-2001 B.S., Nankai University
Professional Experience
◆ 2010.01-2012.09 Research Associate, Division of Life Science, HKUST
◆ 2012.10-now Assistant Professor, SUSTech
Selected Publication
1. Sun Y#*, Guo C#, Ma P, Lai Y, Yang F, Cai J, Sheng Y, Cheng Z, Tian R, Deng Y, Xiao G*, Wu C*. Kindlin-2 association with RhoGDIα suppresses Rac1 activation and podocyte injury. JASN, accepted
2. Hu W#，Yu X#, Liu Z#, Sun Y, Chen X, Yang X, Li X, Lam W, Duan Y, Cao X, Steller H, Liu K, Huang P. TRIP-Br1 mediates degradation of multiple adenylyl cyclase isoforms by XIAP E3 ligase. Elife，2017 Jun 28;6. pii: e28021. doi: 10.7554/eLife.28021.
3. Sun Y*, Huang P*. Adenosine A2B receptor: from cell biology to human diseases. Front Chem. 2016 Aug 24;4:37. doi: 10.3389/fchem.2016
4. Sun Y#, Hu W#, Yu X, Liu Z, Tarran R, Ravid K, Huang P. Actinin-1 binds to the C-terminus of A2B adenosine receptor and enhances its cell surface expression. Biochem J. 2016 Jul 15;473(14):2179-86.
5. Xie C#, Cao X#, Chen X, Wang D, Zhang W, Sun Y, Hu W, Zhou Z, Wang Y, Huang P . Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia. FASEB J. 2016 Apr;30 (4):1579-89.
6. Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam WK, Wang Y, Wu Z, Ravid, K, Huang P. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Journal of Cell Science, 2012 Oct 1;125(Pt 19):4507-17
7. Duan Y, Sun Y, Zhang F, Zhang W, Wang D, Wang Y, Hu W, Xie C, Cuppoleti J, Margin T, Wang H, Wu Z, Li N, Huang P. Keratin K18 increases CFTR surface expression by binding to its C-terminal hydrophobic patch. Journal of Biological Chemistry, 2012 Nov 23;287(48):40547-59.
8. Sun Y # , Wu F # , Sun F, and Huang P. Adenosine promotes IL-6 release in airway epithelia. Journal of Immunology, 2008 Mar 15;180(6):4173-81.
9. Wang D, Sun Y, Zhang W, and Huang P. Apical adenosine regulates basolateral Ca++-activated potassium channels in human airway Calu-3 epithelial cells. Am J of Physiol (Cell Physiology) 294, C1443-C1453, 2008
